目的:研究乳癖消颗粒各提取部位的抗痛经作用。方法:采用缩宫素致小鼠扭体实验观察乳癖消颗粒各提取部位的抗痛经作用。结果:与模型组相比,乳癖消颗粒的各提取部位均能显著减少缩宫素引起的小鼠扭体反应次数(P<0.05,P<0.01或P<0.001);其中,水溶性部位效果最好(P<0.001),且与阳性对照组相比差异无统计学意义(P>0.05)。结论:乳癖消颗粒的水溶性部位具有显著抗痛经作用。 Objective: To study the anti-dysmenorrhea effect of Ruopixiao granule on each extraction site. Methods: The anti-dysmenorrhea effects of Ruopixiao Granules on the extracted parts were observed by writhing test induced by oxytocin in mice. Results: Compared with the model group, each extract of Rupixiao granule could significantly reduce the number of writhing reaction induced by oxytocin in mice (P <0.05, P <0.01 or P <0.001), in which water-soluble sites The effect was the best (P <0.001), and there was no significant difference compared with the positive control group (P> 0.05). Conclusion: Rupixiao particles water-soluble parts have significant anti-dysmenorrhea effect.