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目的观察联合放射性125I粒子植入及高频热疗方案对晚期肺癌人血清促肾上腺皮质激素原氨基端肽(N-POMC)及巨噬细胞抑制因子-1(MIC-1)水平的影响。方法将216例晚期肺癌患者随机分为观察组和对照组各108例,观察组给予联合放射性125I粒子植入及高频热疗方案,对照组给予单纯高频热疗方案治疗。分别对比2组治疗前后血清N-POMC及MIC-1水平变化情况。结果化疗4个疗程后2组N-POMC及MIC-1水平均明显下降,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。结论联合放射性125I粒子植入及高频热疗方案可显著降低肺癌患者血清N-POMC及MIC-1水平。
Objective To observe the effect of combined radioactive 125I seed implantation and high frequency hyperthermia regimen on the levels of serum adrenocorticotrophic peptide (N-POMC) and macrophage inhibitory factor-1 (MIC-1) in patients with advanced lung cancer. Methods A total of 216 patients with advanced lung cancer were randomly divided into observation group (108 cases) and control group (108 cases). The observation group received combined radioactive 125I seeds implantation and high frequency hyperthermia. The control group received simple high frequency hyperthermia treatment. The levels of serum N-POMC and MIC-1 in two groups were compared before and after treatment. Results After 4 courses of chemotherapy, the levels of N-POMC and MIC-1 in two groups were significantly decreased, and the observation group was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Combined radioactive 125I seed implantation and high-frequency hyperthermia can significantly reduce serum N-POMC and MIC-1 levels in patients with lung cancer.