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正电子发射型体层显像(PET)在肿瘤的早期诊断、分期、良恶性鉴别以及复发监测中有着广泛的应用。18F-氟代脱氧葡萄糖(18F-FDG)是目前最成熟的正电子肿瘤显像剂,但是18F-FDG在部分肿瘤中的显像结果并不理想。11C-甲硫氨酸(11C-MET)、11C-乙酸(11C-acetate)、11C-胆碱(11C-choline)、 18F-脱氧胸苷(18F-FLT)等各类非葡萄糖代谢的正电子显像剂逐渐投入临床使用,它们将和18F-FDG 互补,提高各种肿瘤诊断的敏感性、特异性和准确率。
Positron emission tomography (PET) has been widely used in the early diagnosis of tumor, staging, benign and malignant differentiation and recurrence monitoring. 18F-fluorodeoxyglucose (18F-FDG) is by far the most mature positron-tumor imaging agent, however, the imaging results of 18F-FDG in some tumors are not satisfactory. Various non-glucose-metabolizing positrons such as 11C-methionine (11C-MET), 11C-acetate, 11C-choline and 18F-FLT Imaging agents are gradually being put to clinical use and will complement 18F-FDG to increase the sensitivity, specificity and accuracy of various tumor diagnoses.