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目的探讨脑型疟疾合并多器官功能障碍综合征(MODS)的临床诊治特点。方法对乐东县收治的脑型疟疾合并MODS38例的临床资料进行回顾性分析。结果38例脑型疟疾合并MODS占同期脑型疟疾病人的19.75%,受累器官顺序为肺、肾、心、肝、胃肠等;死亡22例,病死率57.89%,显著高于单纯性脑型疟疾的病死率5.18%(P<0.01),病死率随受累脏器数目增多而提高。结论脑型疟疾合并MODS,病情危重、病死率高,应加强监护,采取以抗疟疾、控制脑水肿,改善微循环等为主要措施的综合治疗方法,可降低病死率。
Objective To investigate the clinical diagnosis and treatment of cerebral malaria complicated with multiple organ dysfunction syndrome (MODS). Methods The clinical data of 38 cases of MODS with cerebral malaria admitted in Ledong County were retrospectively analyzed. Results 38 cases of cerebral malaria with MODS accounted for 19.75% of patients with cerebral malaria in the same period. The order of affected organs was lung, kidney, heart, liver, gastrointestinal and so on. 22 cases died, the fatality rate was 57.89%, significantly higher than that of simple brain The case fatality rate of malaria was 5.18% (P <0.01), and the case fatality rate increased with the number of affected organs. Conclusion Cerebral malaria combined with MODS is critically ill and has a high mortality rate. Intensive care should be taken and comprehensive treatment methods such as anti-malaria, cerebral edema control and microcirculation improvement should be taken to reduce mortality.