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目的了解上海市莘庄社区结核病患者药物副反应发生现状及其危险因素,为采取相应的干预措施提供参考依据。方法收集上海市莘庄社区2010年1月1日—2014年12月31日登记的394例结核病患者病历资料和随访信息,分析结核病患者的药物副反应情况及其发生的危险因素。结果上海市莘庄社区394例新登记结核病患者中,发生药物副反应者82例(20.81%);82例发生药物副反应的结核病患者中,肝损异常者33例(40.3%),胃肠道反应者7例(8.5%),关节肌肉痛者12例(14.6%),皮疹者23例(28.1%),视神经损伤者6例(7.3%),高胆红素血症者1例(1.2%);多因素非条件logistic回归结果显示,有合并症是上海市莘庄社区结核病患者发生药物副反应的危险因素(OR=2.166,95%CI=1.114~4.212)。结论上海市莘庄社区结核病患者药物副反应以肝损异常和皮疹为主,有合并症的结核病患者更易发生药物副反应。
Objective To understand the status quo and risk factors of side effects of drugs in patients with tuberculosis in Xinzhuang community of Shanghai and provide reference for taking corresponding interventions. Methods A total of 394 cases of TB patients registered in Shanghai Xinzhuang Community from January 1, 2010 to December 31, 2014 were collected and their follow-up information was collected to analyze the side effects of the drugs and their risk factors. Results Among the 394 newly registered tuberculosis patients in Xinzhuang community of Shanghai, 82 (20.81%) were drug side-effects and 82 (40.3%) had abnormal liver damage. Of the 82 patients with drug-induced tuberculosis, There were 7 cases (8.5%) of responders, 12 cases (14.6%) of joint muscle pain, 23 cases of rash (28.1%), 6 cases of optic nerve injury (7.3%) and 1 case of hyperbilirubinemia %). Multivariate non-conditional logistic regression analysis showed that the complication was the risk factor for adverse drug reactions in patients with tuberculosis in Xinzhuang community in Shanghai (OR = 2.166, 95% CI = 1.114-4.212). Conclusions The side effects of drugs in patients with tuberculosis in Xinzhuang community in Shanghai are mainly liver abnormalities and skin rashes. Patients with tuberculosis with complications are more likely to have side effects.