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目的 探讨铅、镉、砷等职业有害因素致人外周血淋巴细胞染色体畸变的特征性改变。方法 采集职业作业人群及正常人群外周血淋巴细胞培养 72h ,观察染色体畸变类型及其特征。结果 因镉污染接触人群及实验室条件下对淋巴细胞进行高浓度染铅时染色单体互换畸变细胞率为 0 ;染砷浓度 <0 1mg/L时未发生染色单体互换 ,染砷浓度达 0 2～ 0 4mg/L时染色单体互换畸变细胞率为 1 2 4%。 结论 染色单体互换畸变细胞率的增加与接触因素砷及砷的浓度密切相关 ,砷是否可作为染色单体互换产生的主要原因还需作进一步深入的研究
Objective To investigate the characteristic changes of chromosomal aberrations in human peripheral blood lymphocytes caused by occupational harmful factors such as lead, cadmium and arsenic. Methods Peripheral blood lymphocytes (PBLs) of professional workers and normal controls were collected for 72 hours. The types of chromosomal aberrations and their characteristics were observed. The results showed that when the concentration of lead arsenic was less than 0 1 mg / L, there was no chromophore exchange and staining of arsenic Concentration of 0 2 ~ 0 4mg / L chromatid exchange rate of cell aberration was 1 2 4%. Conclusion The increase of chromatid exchange rate is closely related to the concentration of arsenic and arsenic, and whether arsenic can be used as the main reason of chromatid exchange needs further study