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探讨中国人胰腺癌的发生与糖尿病等疾病及家族史的关系。以 4 93例病理确诊的胰腺癌患者作为病例组 ,10 31例非肿瘤患者年龄和性别、经济收入频数匹配的同来源病例为对照组 ,用病例对照研究的方法计算比值比 (OR)及 95 %可信区间 (CI) ,以估计糖尿病等病史及家族史的相对危险性。结果表明 ,诊断胰腺癌 2年以上患糖尿病、胆石症、慢性胰腺炎、癌症、肺结核病、幽门螺杆菌感染、癌症家族史和糖尿病家族史的OR值 (95 %CI)分别为 4 .6 4 (2 0 5～ 10 4 9)、4 12 (2 81～6 0 4 )、18 38(6 33～ 5 3 35 )、9 4 7(4 97～ 18 0 6 )、4 2 1(2 30～ 7 72 )、1 14 (0 4 5～ 2 89)、2 0 1(1 2 9～3 14 )、0 83(0 15～4 5 6 )。糖尿病和胆石症Logistic回归分析P <0 0 5。因此糖尿病、胆石症、胰腺炎、癌症史、肺结核病史及癌症家族史是胰腺癌的危险因素 ,而糖尿病和胆石症是其独立危险因素
To investigate the relationship between the occurrence of pancreatic cancer and other diseases and family history in Chinese. A total of 4 93 pancreatic cancer patients with pathological diagnosis were selected as the case group. The age, gender, and income frequency matched source cases among 10 31 non-tumor patients were used as control group. The case-control study was performed to calculate the odds ratio (OR) and 95 % Confidence interval (CI) to estimate the relative risk of history and family history of diabetes. The results showed that the odds ratio (95% CI) of the diagnosis of pancreatic cancer more than 2 years with diabetes, cholelithiasis, chronic pancreatitis, cancer, pulmonary tuberculosis, Helicobacter pylori infection, family history of cancer and family history of diabetes were 4.64 (2 0 5 to 10 4 9), 4 12 (2 81 to 6 0 4), 18 38 (6 33 to 5 3 35), 9 4 7 (4 97 to 18 0 6), 4 2 1 (2 30 ~ 7 72), 1 14 (0 4 5 ~ 2 89), 2 0 1 (1 2 9 ~ 3 14), 0 83 (0 15 ~ 4 5 6). Logistic regression analysis of diabetes and cholelithiasis P <0 05. Therefore, diabetes, cholelithiasis, pancreatitis, cancer history, history of tuberculosis and family history of cancer are risk factors for pancreatic cancer, while diabetes and cholelithiasis are independent risk factors