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目的:了解补肾壮骨胶囊对卵巢切除大鼠骨质疏松症的治疗作用。方法:采用临床检验方法测定补肾壮骨胶囊对卵巢切除大鼠血清钙、磷、血清碱性磷酸酶的影响,用骨形态计量学方法检测补肾壮骨胶囊对卵巢切除大鼠右后肢股骨治疗反应。结果:与假手术组相比,模型对照组的血钙、血磷显著下降,碱性磷酸酶升高。相对骨体积明显缩小(P<0.01)。与模型对照组相比,补肾壮骨胶囊高、低剂量组血钙、血磷显著升高,碱性磷酸酶下降,相对骨体积明显增加(P<0.05)。结论:补肾壮骨胶囊对卵巢切除大鼠骨质疏松症有明显的防治作用。
Objective: To understand the therapeutic effect of Bushen Zhuanggu capsule on osteoporosis in ovariectomized rats. METHODS: Clinical test was used to determine the effect of Bushen Zhuanggu capsule on serum calcium, phosphorus, and serum alkaline phosphatase in ovariectomized rats. Bone histomorphometry was used to detect the effect of Bushen Zhuanggu capsule on the treatment of femur in the right hindlimb of ovariectomized rats. . RESULTS: Compared with the sham group, the serum calcium and phosphorus levels in the model control group were significantly decreased, and alkaline phosphatase was elevated. The relative bone volume was significantly reduced (P<0.01). Compared with the model control group, the serum calcium and phosphorus levels in the high- and low-dose groups of Bushen Zhuanggu capsule were significantly increased, alkaline phosphatase was decreased, and the relative bone volume was significantly increased (P<0.05). Conclusion: Bushen Zhuanggu Capsule has obvious preventive and therapeutic effects on osteoporosis in ovariectomized rats.