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目的 :调查苯丙醇胺 (PPA)和出血性中风发病的相关性。方法 :蛛网膜下腔出血 (SAH)或颅内出血(ICH)的 18～ 4 9岁男性和女性住院患者的病例对照研究。合格的病例是既往无中风史 ,并能在发病 3 0d内接受面谈的患者。这些病例均从美国的四个不同地区的医院中选出。对于每个病例 ,采用随机数字法确定两例对照 ,并在年龄、性别、种族以及telephoneexchange方面进行匹配。病例和对照者均须接受访谈以确定他们的病史、健康行为以及用药情况。所谓暴露于PPA ,对于病例组是指在中风的前 3d内使用过PPA ,对于对照则是指在相应的时间内用过PPA。结果 :研究对象包括 70 2名病例和 13 76名对照。在性别和telephoneexchange方面所有对照均与病例匹配 ;年龄配对成功者 13 67例 ( 99% ) ,种族配对成功者 13 2 1例 ( 96% )。中风前 3d内使用PPA与出血性中风的校正比值比为 1.4 9[单侧 95 %可信区间的下限 (LCL) =0 .93 ,P =0 .0 84 ];PPA用作感冒治疗药与出血性中风的校正比值比为 1.2 3 (LCL =0 .75 ,P =0 .2 4 5 ) ;PPA用作食欲抑制剂与出血性中风的校正比值比为 15 .92(LCL =2 .0 4 ,P =0 .0 13 ) ;PPA作为食欲抑制剂和女性出血性中风的校正比值比为 16.5 8(LCL =2 .2 2 ,P =0 .0 11) ;在首剂使用PPA的女性中 ,校正比
PURPOSE: To investigate the association between phenylpropanolamine (PPA) and hemorrhagic stroke. METHODS: A case-control study of inpatients between 18 and 49 years of age in males and females with subarachnoid hemorrhage (SAH) or intracranial hemorrhage (ICH) was performed. Eligible cases were history of stroke-free history and were interviewed within 30 days of onset. These cases were selected from hospitals in four different parts of the United States. For each case, a random number was used to determine the two controls and matched for age, gender, ethnicity, and telephoneexchange. Both cases and controls were interviewed to determine their medical history, health behaviors and medication status. The so-called exposure to PPA, for the case group refers to the use of PPA within the first three days of stroke, for the control refers to the use of PPA in the corresponding period of time. Results: The subjects included 70 2 cases and 13 76 controls. All controls were gender matched and telephoneexchange matched with cases; 13 67 (99%) were successful in age pairing, and 13 2 1 (96%) were race partners successfully. The adjusted odds ratio for PPA to hemorrhagic stroke was 1.4 9 within 3 days before stroke (LCL = 0.93, P = 0.84 84 for unilateral 95% confidence interval); PPA was used as a cold treatment drug The adjusted odds ratio for hemorrhagic stroke was 1.2 3 (LCL = 0.75, P = 0.245); the corrected ratio of PPA for appetite suppressant to hemorrhagic stroke was 15.92 (LCL = 2.0 4, P = 0.013). The corrected odds ratio of PPA as an appetite suppressant and female hemorrhagic stroke was 16.58 (LCL = 2.222, P = 0.011). In the first dose of female PPA In the correction ratio