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Objective: This study was undertaken to compare survival and morbidity until discharge in infants born after 22-23 versus 24 weeks’gestational age(GA). Study design: Cohort study of all infants 25 weeks or less, born in 3 tertiary perinatal centers (1999-2003). Results: Of a total of 336 infants, 133(40%) died before or immediately after birth without the provision of life support, 203(60%) received active neonatal treatment. Infants with life support(n=82 at 22 to 23 weeks, n=121 at 24 weeks) differed with respect to antenatal steroid prophylaxis (44%vs 62%) and cesarean section rate (51%vs 71%). Survival was 67%compared with 82%(P=.016). The incidence of intraventricular hemorrhage III or greater or periventricular leukomalacia(15/15%), severe retinopathy of prematurity(18/15%), and chronic lung disease (40/47%) was similar in both GA groups. Conclusions: The provision of life support for extremely preterm infants increases their chance of survival without more neonatal morbidity.
Objective: This study was undertaken to compare survival and morbidity until discharge in infants born after 22-23 versus 24 weeks’ gestational age (GA). Study design: Cohort study of all infants 25 weeks or less, born in 3 tertiary perinatal centers ( (60%) received active neonatal treatment. Infants with life support (n = 82 (40%) died before or immediately after birth without the provision of life support, 203 at 22 to 23 weeks, n = 121 at 24 weeks) were significantly more likely to have antenatal steroid prophylaxis (44% vs 62%) and cesarean section rate (51% vs 71% .016). The incidence of intraventricular hemorrhage III or greater or periventricular leukomalacia (15/15%), severe retinopathy of prematurity (18/15%), and chronic lung disease (40/47%) was similar in both GA groups. Conclusions: The provision of life support for extremely preterm infants increase their chance of survival without more neonatal morbidity.