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目的探讨新辅助化疗对乳腺癌保乳手术患者的疗效。方法选取2009年1月至2012年1月间收治的行新辅助化疗后符合保乳术条件的乳腺癌患者68例,观察患者的术后疗效、安全性并对比手术前后患者的生活质量。结果 68例患者中,完全缓解11例(16.2%),部分缓解36例(52.9%),病情稳定21例(30.9%),无进展病例,总分期降低38例(55.9%)。与治疗前相比,患者生活质量得到显著提高(P<0.05)。68例患者在化疗期间出现白细胞减少27例,脱发17例,恶心呕吐34例,经对症治疗后,患者不良反应均缓解。结论新辅助化疗对乳腺癌保乳手术患者肿瘤缓解疗效显著,不良反应轻微。
Objective To investigate the effect of neoadjuvant chemotherapy on breast-conserving surgery patients with breast cancer. Methods Sixty-eight breast cancer patients who underwent neoadjuvant chemotherapy were enrolled from January 2009 to January 2012. The postoperative efficacy and safety of the patients were observed and the quality of life of the patients before and after surgery was compared. Results Among 68 patients, complete remission was achieved in 11 cases (16.2%), partial remission in 36 cases (52.9%), stable condition in 21 cases (30.9%), progression free cases and total reduction in 38 cases (55.9%). Compared with before treatment, patients’ quality of life was significantly improved (P <0.05). In the 68 patients, there were 27 cases of leukopenia, 17 cases of hair loss and 34 cases of nausea and vomiting during chemotherapy. After symptomatic treatment, the adverse reactions of patients were relieved. Conclusion Neoadjuvant chemotherapy has a significant effect on the tumor remission in breast-conserving surgery patients with mild adverse reactions.