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目的 :研究加倍与常规剂量奥曲肽治疗肝硬化食管静脉曲张破裂出血的疗效。方法 :肝硬化食管静脉曲张破裂出血病人 4 3例次 (男性 2 8例次 ,女性 15例次 ) ,年龄 5 6a±s 14a。分常规剂量 (10 0μg ,iv ,继以 2 5 μg·h- 1静脉滴注维持 )组 33例次 ,加倍剂量 (10 0 μg ,iv ,继以 5 0 μg·h- 1静脉滴注维持 )组 10例次。结果 :加倍剂量组与常规剂量组的止血率分别为 90 % (9/ 10 ) ,76 % (2 5 / 33) ,2组之间差异无显著意义 (P >0 .0 5 ) ;其中 5例次应用常规剂量无效者改用加倍剂量后出血得到控制。肝功能分级与奥曲肽的止血率之间差异无显著意义 (P >0 .0 5 )。结论 :奥曲肽是治疗肝硬化食管静脉曲张破裂出血的有效药物。常规剂量无效者改用加倍剂量仍可获得较好的止血效果
Objective: To study the curative effect of doubling and conventional dosage of octreotide in the treatment of hepatic cirrhosis with esophageal variceal bleeding. Methods: Forty-three patients (28 males and 15 females) with cirrhosis and esophageal variceal bleeding were aged 5 6a ± s 14a. The rats in the control group were treated with intravenous drip (50 μg · h-1, iv, followed by intravenous infusion of 25 μg · h-1) ) Group of 10 cases. Results: The hemostatic rates of doubled dose group and conventional dose group were 90% (9/10) and 76% (25/33), respectively. There was no significant difference between the two groups (P> 0.05) Cases of conventional dose ineffective switch to doubling the dose after the bleeding control. No significant difference was found between the grade of hepatic function and the rate of hemostasis of octreotide (P> 0.05). Conclusion: Octreotide is an effective drug for the treatment of hepatic cirrhosis and esophageal variceal bleeding. Conventional dose ineffective switch to double the dose can still get better hemostatic effect