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目的:探讨脉搏波速度(PWV)和颈动脉内中膜厚度(IMT)对冠状动脉(冠脉)粥样硬化的预测价值及其联合应用的意义。方法:随机选择102例行冠脉造影检查的患者同时行PWV、IMT测定,用SYNTAX积分评价冠脉病变的程度;分别用PWV、IMT预测冠心病并比较两者联合应用诊断的可靠程度。结果:①以SYN-TAX积分判定冠脉正常组、病变轻、中、重组间PWV差异有统计学意义(P<0.001),冠脉病变越严重PWV越高;冠脉正常组、各病变组间IMT差异有统计学意义(P<0.001),冠脉病变越严重IMT越大。②分别作PWV、IMT预测冠心病的ROC曲线,PWV=11.50m/s预测冠心病的灵敏度为78.8%,特异度为86.4%;IMT=1.50mm预测冠心病的灵敏度为77.3%,特异度为64.3%。③两者联合应用的灵敏度为95.1%,特异度为95.1%。结论:PWV、IMT和冠脉粥样硬化程度有密切关系;联合应用两种方法检测冠脉病变程度可以提高敏感性和特异性。
Objective: To investigate the predictive value of pulse wave velocity (PWV) and carotid intima-media thickness (IMT) on coronary artery (coronary) atherosclerosis and its significance. Methods: 102 patients undergoing coronary angiography were randomly selected to perform PWV and IMT simultaneously. SYNTAX score was used to evaluate the degree of coronary artery disease. Coronary heart disease was predicted by PWV and IMT, respectively, and their reliability was evaluated. Results: ①With the SYN-TAX score, there was significant difference in PWV between normal group and mild group (P <0.001), and the more severe coronary artery disease was, the higher PWV was. Coronary normal group, each lesion group There was significant difference between IMT (P <0.001), and the more serious coronary lesions were IMT. ② The ROC curves of PWV and IMT were respectively calculated. PWV = 11.50m / s predicted the sensitivity and accuracy of coronary heart disease to be 78.8% and 86.4% respectively; the sensitivity and specificity of predicting coronary heart disease to IMT = 1.50mm and 77.3% 64.3%. ③ the combined sensitivity of the two was 95.1%, the specificity was 95.1%. Conclusion: PWV and IMT are closely related to the degree of coronary atherosclerosis. The combination of two methods to detect the degree of coronary artery lesion can improve the sensitivity and specificity.