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胆囊粘蛋白在胆固醇结石的发病机理上起重要作用,它存在于结石核心区并在壳内形成网络,其分泌由前列腺素及其前体所介导,而阿司匹林或NSAID抑制前列腺素合成可减少胆囊粘膜分泌的粘蛋白,从而得以防止胆固醇结石的形成。美国弗吉尼亚州医学院曾在对230例肥胖病人施行胃转流手术中进行B超扫描检查,发现胆囊结石80例,从中选出18例长期服用NSAID者(指连续2个月以上)进行分析,并与下列3组进行对比:(1)有胆囊结石而未服
Gallstone mucin plays an important role in the pathogenesis of cholesterol stones. It exists in the core of the calculus and forms a network in the shell, which is mediated by prostaglandins and their precursors, while aspirin or NSAID inhibits prostaglandin synthesis Gallbladder mucus secretion of mucin, which can prevent the formation of cholesterol stones. Virginia Medical College in the United States in 230 cases of obese patients undergoing gastric bypass surgery by B-scan and found that gallbladder stones in 80 cases, 18 were selected from the long-term use of NSAID who (for more than 2 months) for analysis, And compared with the following three groups: (1) without gallstone gallstone