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目的观察依达拉奉预防急性颅脑损伤后尿崩症情况。方法将492例急性颅脑损伤的患者,随机分为实验组与对照组各246例。实验组在常规治疗的基础上,给予依达拉奉30mg加入生理盐水100ml静脉滴注,30min内滴完,2次/d,14d为1个疗程。结果实验组与对照组间尿崩症发生率差异有统计学意义(P<0.01)。结论早期应用依达拉奉治疗急性颅脑外伤,可以预防及减少颅脑伤后尿崩症这一并发症的发生率。
Objective To observe the effect of edaravone in preventing diabetes insipidus after acute craniocerebral injury. Methods 492 patients with acute craniocerebral injury were randomly divided into experimental group and control group with 246 cases each. On the basis of routine treatment, the experimental group was given Edaravone 30mg intravenously by adding 100ml of normal saline, drip finished within 30min, 2 times / d, 14d as a course of treatment. Results There was significant difference in the incidence of diabetes insipidus between the experimental group and the control group (P <0.01). Conclusion The early application of edaravone in the treatment of acute craniocerebral injury can prevent and reduce the incidence of diabetes insipidus complication after craniocerebral injury.