浸润转移是恶性肿瘤的本质特征,也是肿瘤患者死亡的主要原因。基质金属蛋白酶-9(MMP-9)是一种与肿瘤浸润转移密切相关的物质,近来发现它也与肿瘤血管形成有关,因而成为当前研究肿瘤浸润转移的热点。血管内皮生长因子(VEGF)除对正常生理性血管形成和病理性血管形成都起着重要调节作用,其结构特征和生物学特性使之在为缺血性组织重建侧支循环、肿瘤转移、肿瘤预后乃至基因治疗等领域成为重要的研究对象。 Invasion and metastasis is an essential feature of malignant tumors, but also the main cause of death of cancer patients. Matrix metalloproteinase-9 (MMP-9), a substance closely related to tumor invasion and metastasis, has recently been found to be involved in tumor angiogenesis and has become a current hot spot in the study of tumor invasion and metastasis. Vascular endothelial growth factor (VEGF) plays an important regulatory role in both normal physiological angiogenesis and pathological angiogenesis. Its structural features and biological characteristics make it useful for the reconstruction of collateral circulation, tumor metastasis, tumor Prognosis and even gene therapy and other fields has become an important research object.