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目的探讨荧光原位杂交技术在检测染色体数目异常与自然流产的关系及影响因素。方法应用荧光原位杂交技术对539例早期自然流产绒毛进行染色体数目异常检查及其与患者的年龄、流产次数之间的联系。结果 539例流产绒毛标本中,共检测出133例染色体数目异常,其中常染色体三体最多,共计81例(60.9%);性染色体数目异常22例(16.5%);多倍体30例(22.5%);绒毛染色体数目异常与正常年龄组和高龄组之间的比较,高龄组异常发生率高;而流产次数3次及3次以上的染色体数目异常发生率(29.5%)高于流产次数为2次及2次以下者(20.3%)。结论染色体数目异常是胚胎停育流产的重要因素,其中以常染色体三体为主;胚胎停育与孕妇年龄有关;对于流产次数3次及3次以上的流产患者,建议检查绒毛染色体数目异常很有必要。
Objective To investigate the relationship between the number of abnormal chromosomes and spontaneous abortion by fluorescence in situ hybridization and its influencing factors. Methods Fluorescence in situ hybridization (FISH) was used to examine the chromosomal abnormalities in 539 cases of spontaneous abortion and its relationship with the age of patients and the number of abortions. Results A total of 133 chromosomal abnormalities were detected in 539 cases of abortion. Among them, 81 cases (60.9%) had the most autosomal trisomy, 22 cases (16.5%) had abnormal sex chromosomes, 30 cases (22.5 cases) %). The abnormal chromosome number in chorionic villi was higher than that in normal and advanced age groups. The incidence of abnormal chromosomes in high-grade group was higher than that in normal group (29.5%) 2 times and less than 2 times (20.3%). Conclusion Abnormal number of chromosomes is an important factor in the abortion of aborted fetuses, of which the autosomal trisomies are dominant, and the suspension of embryos is related to the age of pregnant women. For abortion with 3 or more abortions, it is recommended to check the abnormal chromosome number Is necessary.