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[目的]评估膀胱癌术后辅助性膀胱内丝裂霉素联合卡介苗灌注或单用表阿霉素灌注对生活质量的影响。[方法]75例膀胱癌术后膀胱内灌注患者于术前、灌注第6周、12周及48周后调查生活质量和毒副作用,生活质量量表采用改良的AndreasBohle调查表。调查率达95%和97%。[结果]生活质量评分在不同治疗组间、治疗的不同阶段差异无显著性;两组主要的毒副反应为全身不适、下腹痛、小便时烧灼感、小便粘滞感、乏力等,发生率差异均无显著性。[结论]膀胱癌术后辅助性MMC/BCG或EPI-ADM膀胱内灌注对患者的生活质量影响轻微。
[Objective] To evaluate the effect of postoperative adjuvant intravesical MMC plus BCG infusion or epirubicin perfusion on quality of life in patients with bladder cancer. [Methods] The quality of life and side effects of 75 patients with bladder cancer after intravesical instillation were investigated preoperatively, 6 weeks, 12 weeks and 48 weeks after perfusion. The quality of life questionnaire was modified by Andreas Bohle questionnaire. Investigation rates reached 95% and 97%. [Results] There were no significant differences in the quality of life scores between different treatment groups at different stages of treatment. The main adverse reactions in the two groups were general malaise, lower abdominal pain, burning sensation during urination, viscous stool, fatigue and so on There was no significant difference. [Conclusion] Intravesical infusion of adjuvant MMC / BCG or EPI-ADM after bladder cancer has a slight effect on the quality of life of patients.