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异汉防己甲素(以下简称异甲素)系双苄基异喹啉类生物硷。已报导汉防己甲素对大鼠实验性矽肺有一定疗效,临床上用汉防己甲素及异甲素治疗矽肺患者,发现病情有稳定趋势。为此,我们从贵州细叶十大功劳中提取的异甲素,对大鼠进行了实验性矽肺的疗效观察,目的是为寻求治疗矽肺新药物提供依据。兹将实验结果报告如下: 实验方法动物选择:选择体重180—220克雄性健康大鼠42只,随机分对照组、预防治疗组、病后治疗组。每组大鼠14只。粉尘:用含游离SiO_2>99％,分散度<5微米以下者占95％。粉尘对大鼠染尘预试验30
Heterotetracycline (hereinafter referred to as isoform A) is a bis-benzyl isoquinoline bio-germanium. It has been reported that tetrandrine has a certain curative effect on experimental silicosis in rats. Clinically, patients with silicosis treated with tetrandrine and isopropyl were found to have a stable tendency. To this end, we have extracted the isoforcin extracted from the Guizhou Lobelia magnifica and observed the efficacy of experimental silicosis in rats. The aim is to provide evidence for seeking new drugs for silicosis. The experimental results are reported as follows: Experimental methods Animal selection: 42 healthy male rats weighing 180-220 g were randomly divided into a control group, a preventive treatment group, and a post-treatment group. 14 rats in each group. Dust: The use of free SiO2> 99%, dispersion <5 microns accounted for 95%. Dust pre-testing on rats 30