论文部分内容阅读
肺癌及其传代细胞中普遍存在特征性的基因异常。本文综述了显性癌基因K-ras及抑癌基因P_(53)的研究进展。 P_(53)突变 正常P_(53)是抑癌基因,其编码产物能与维持细胞恶性转化的SV_(40)大T抗原结合。对细胞的生长与分裂起负调节作用。而突变后的P_(53)则有促进细胞分裂的作用,促进癌的发生与生长。P_(53)突变在肺癌中好发于与大T抗原结合的部位, 但基因全长均可发生突变。研究表明100％(n=25)的小细胞肺癌(SCLC)传代细
The characteristic genetic abnormalities are common in lung cancer and its passaged cells. This article reviews the research progress of the dominant oncogene K-ras and tumor suppressor gene P_ (53). P_53 mutations Normal P_53 is an anti-oncogene and its encoded product can bind to the SV_40 large T antigen that maintains malignant transformation of cells. It negatively regulates cell growth and division. The mutated P_53 promotes cell division and promotes the occurrence and growth of cancer. The P_53 mutation in lung cancer occurs at the site of binding to the large T antigen, but the full-length gene can be mutated. Studies show that 100% (n=25) SCLC passages are fine