以苯胺为原料,经重氮化、偶合、还原得到4-羟基-5-乙氧基苯胺。合成中,通过保险粉还原偶氮化合物的方法在芳香环上引进氨基,不仅产物收率高(总收率86%,较文献提高了26.3%),而且还原产物容易分离,粗品纯度可达95%。本合成路线中间体均不经提纯,且氨基的引入中避免了贵金属的加氢还原,是一条适合大规模生产4-羟基-5-乙氧基苯胺的新合成工艺路线。 Aniline as raw material, diazotization, coupling, reduction 4-hydroxy-5-ethoxyaniline. Synthesis, the reduction of azo compounds by the insurance method of the introduction of aromatic amino ring, not only high product yield (86% of the total yield, compared with the literature increased by 26.3%), and the reduction of products easily separated, the purity of crude products up to 95 %. The synthesis route intermediates are not purified, and the introduction of amino to avoid the hydrogenation of precious metals, is a suitable large-scale production of 4-hydroxy-5-ethoxyaniline new synthetic route.