Objective: To systematically evaluate the effect of marine Omega-3 polyunsaturated fatty acids (Omega-3 PUFA) on adiponectin and leptin levels in overweight and obese patients. Methods: The computer searched PubMed, Embase, Cochrane Library and CNKI electronic databases for randomized controlled experiments on the levels of marine Omega-3 PUFA and adiponectin and leptin in overweight and obese patients. The two researchers independently screened, evaluated and included the literatures and extracted the data.Meta analysis was carried out with Revman 5.3 software. Results: A total of 8 articles and 607 subjects were included. The results showed that Omega-3 PUFA from marine sources did not increase in adiponectin levels [SMD=0.32, 95％CI=(-0.13, 0.76) ],while there was no significant did not reduce the leptin level of patients [SMD=-0.22, 95％CI=(-0.53, 0.09)]. Conclusion: Marine-derived Omega-3 PUFA can improve circulating leptin and adiponectin levels in overweight and obese patients, increase serum adiponectin levels and reduce leptin levels, but the difference is not obvious. Further research is still needed to determine the effect of Omega-3 PUFA on Adipokine in overweight and obese people.