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目的:通过清洁手术干预前后预防使用抗菌药物情况的对比分析,考查干预措施的实施效果。方法:选取2009年6月-2010年7月(非干预组)及2011年6月-2012年6月(干预组)清洁手术病例,对比干预前后预防应用抗菌药物的合理性。结果:干预后,抗菌药物在预防使用率、适应证、药物选择、用法用量、给药时机、药物疗程、联合用药方面较干预前有明显改善;平均住院抗菌药物费用占平均住院总费用的比例由11.3%降至5.7%,差异显著,平均住院药品费用和平均住院总费用均有所下降,平均住院天数减少0.9 d。结论:干预效果显著,干预措施是有效、可行的,但仍存在疗程过长、预防率略高等问题。
OBJECTIVE: To evaluate the effectiveness of interventions by comparing and analyzing the use of antimicrobials before and after the operation of clean surgical interventions. Methods: The cases of clean operation between June 2009-July 2010 (non-intervention group) and June 2011-June 2012 (intervention group) were selected to compare the rationality of preventive antibiotics before and after intervention. Results: After the intervention, the antibacterials showed a significant improvement compared with that before the intervention in terms of prevention use, indications, choice of drugs, dosage, timing of administration, drug treatment and combination therapy. The average proportion of hospitalized antibacterial drugs in the total hospitalization costs From 11.3% to 5.7%, the difference was significant. The average cost of hospitalization and the average hospitalization expenses decreased while the average hospitalization days decreased by 0.9 days. Conclusion: The effect of intervention is significant, interventions are effective and feasible, but there are still some problems such as long course of treatment and slightly higher prevention rate.