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[目的]观察黄芪益肾汤联合西药治疗早期糖尿病肾病疗效。[方法]使用随机平行对照方法,将116例住院患者抛硬币法简单随机分为两组。对照组58例格列齐特,80mg/次,1次/d;贝那普利,开始一周10mg/d,后20mg/d,1次/d。治疗组58例黄芪益肾汤(生黄芪40g,大黄15g,白术、五味子各20g,熟地15g,丹参30g,葛根20g,杜仲25g,生地15g,牛膝30g,山药20g,白芍、茜草、连翘各5g),1剂/d,水煎200m L,早晚口服;西药治疗同对照组。连续治疗60d为1疗程。观测临床症状、FPG、BUN、Scr、24h尿蛋白定量、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效24例,有效28例,无效6例,总有效率89.66%。对照组显效16例,有效26例,无效16例,总有效率72.41%。治疗组疗效优于对照组(P<0.05)。[结论]黄芪益肾汤联合西药治疗早期糖尿病肾病效果显著,值得推广。
[Objective] To observe the curative effect of Huangqi Yishen Decoction combined with western medicine on early diabetic nephropathy. [Method] Randomized parallel method was used to randomly divide 116 hospitalized patients into two groups randomly. Control group, 58 cases of gliclazide, 80mg / time, 1 / d; benazapril, the beginning of a week 10mg / d, after 20mg / d, 1 / d. The treatment group 58 cases of Astragalus Yishen Decoction (raw Astragalus 40g, Rhubarb 15g, Atractylodes, Schisandra each 20g, Rehmannia 15g, Salvia 30g, Pueraria 20g, Eucommia 25g, habitat 15g, Achyranthes 30g, yam 20g, white peony, Alice each 5g), 1 / d, decoction 200m L, morning and evening oral; western medicine treatment with the control group. Continuous treatment of 60d for a course of treatment. Observed clinical symptoms, FPG, BUN, Scr, 24h urine protein quantitation, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Result] The treatment group was effective in 24 cases, effective in 28 cases, ineffective in 6 cases, the total effective rate was 89.66%. Control group markedly effective in 16 cases, effective in 26 cases, ineffective in 16 cases, the total effective rate was 72.41%. The treatment group was better than the control group (P <0.05). [Conclusion] Astragalus Yishen Decoction combined with western medicine has significant effect on early diabetic nephropathy and is worth promoting.