在与外界环境接触中肠黏膜屏障具有阻止肠腔内有害物质如致病微生物、抗原和促炎因子进入血液循环维护人体健康的作用。它由非免疫屏障和免疫屏障两部分组成。当他们受到损害时可导致肠道细菌移位和促炎因子大量释放,从而加重原发疾病,甚至诱发多脏器功能衰竭的发生。而益生菌、谷氨酰胺、表皮生长因子和转化生长因子-α、三叶因子和磷酸二酯酶抑制剂等对肠黏膜屏障功能具有保护作用。 In contact with the external environment in the intestinal mucosal barrier with the intestine to prevent harmful substances such as pathogenic microorganisms, antigens and anti-inflammatory factors into the blood circulation to maintain human health role. It consists of non-immune barrier and immune barrier in two parts. When they are damaged, they can cause intestinal bacterial translocation and the release of a large number of proinflammatory cytokines, thereby aggravating the primary disease and even inducing multiple organ failure. Probiotics, glutamine, epidermal growth factor and transforming growth factor-alpha, trefoil factor and phosphodiesterase inhibitors and other protective effects on intestinal mucosal barrier function.