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目的研究波棱甲素纳米混悬剂的制备及其胶囊体外溶出度的测定。方法采用高压均质法制备波棱甲素纳米混悬剂,并分别将波棱甲素纳米混悬剂和波棱甲素物理混合物制成胶囊,以pH 7.5的磷酸盐缓冲液为溶出介质,采用桨法测定体外溶出度,比较波棱甲素纳米混悬剂胶囊和波棱甲素物理混合物胶囊的溶出速率和溶出量。结果采用高压均质法制备的波棱甲素纳米混悬剂胶囊的体外累积溶出度明显高于波棱甲素物理混合物胶囊(P<0.01)。结论高压均质法制备波棱甲素纳米混悬剂的工艺简单易行,波棱甲素纳米混悬剂能显著提高药物的体外溶出度。
Objective To study the preparation of rifampicin nanosuspension and its in vitro dissolution test. Methods A high-pressure homogenization method was adopted to prepare rivertosin nanosuspension. Capsules were made by mixing the rifampicin nanosuspension and promethazine respectively. The pH 7.5 phosphate buffer was used as the dissolution medium, The dissolution rate in vitro was determined by paddle method. The dissolution rate and dissolution rate of capsules containing rifampicin nanosuspensions and rifampicin physical mixture were compared. Results The dissolution of rifampicin nanosuspensions prepared by high pressure homogenization was significantly higher than that of ribonucleoside mixture (P <0.01). Conclusion High pressure homogenization method for the preparation of ribonucleic acid nano-suspension is simple and easy. The rifampicin nano-suspension can significantly improve the in vitro dissolution of the drug.