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HCG(人绒毛膜促性腺激索)主要是由绒毛膜合体滋养层细胞分泌的一种精蛋白激素,约含糖30％,分子体积为45,000～50,000Daltons,其功能是:一方面刺激黄体产生维持妊娠所必须的孕激素,另一方面则承担保护胎儿不受母体免疫拒绝反应的影响。故若能以抗HCG抗体中和绒毛膜分泌的HCG阻止孕激素的生成,不仅能损伤着床的受精卵,而且对绒毛细胞有毒性作用,使妊娠中断于早期。 HCG与同类激素中的促黄体激素 (LH),促卵泡激素(FSH),促甲状腺激素(TSH)一样,具有四级结构,由α和β亚基组成(结构如表1)α亚基含有HCG2/7的糖分子,由92个氨基酸残基组成,分子体积为15,000～20,000 Daltons;β亚基含有
HCG (Human Chorionic Gonadotropin) is a protamine hormone secreted by chorionic trophoblast cells. It contains about 30% of sugars and has a molecular volume of 45,000-50,000 Daltons. Its function is to stimulate the production of lutein Maintains the pregnancy necessary for progesterone, on the other hand assumes the protection of the fetus from maternal immune rejection reaction. Therefore, if anti-HCG antibodies and chorionic secretion of HCG prevent the generation of progesterone, not only can damage the implantation of fertilized eggs, but also toxic to the villus cells, so that pregnancy interrupted in the early. HCG with the same hormone in the luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), has a four-level structure, composed of α and β subunits (structure shown in Table 1) α subunit contains The HCG2 / 7 sugar molecule consists of 92 amino acid residues with a molecular volume of 15,000-20,000 Daltons; the beta subunit contains