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局部亚低温和细胞移植可明显减轻缺血性脑损伤和抑制凋亡。局部亚低温通过多种机制发挥神经保护作用,以抑制脑梗死后所激活的细胞凋亡途径中的caspase-3和细胞凋亡诱导因子表达,促X染色体连锁的凋亡抑制蛋白表达,减少神经细胞凋亡为重要途径。在细胞移植抗凋亡中,成纤维细胞生长因子和神经营养因子作为移植细胞所分泌的体液因子,对脑梗死后神经细胞具有保护作用。现综述局部亚低温和细胞移植对脑梗死后神经保护作用及其机制。
Local mild hypothermia and cell transplantation can significantly reduce ischemic brain damage and inhibit apoptosis. Local mild hypothermia exerts neuroprotective effects through various mechanisms to inhibit the expression of caspase-3 and apoptosis-inducing factor in the apoptotic pathway activated by cerebral infarction, promote the expression of X-linked inhibitor of apoptosis protein, and decrease the number of nerve Apoptosis is an important way. In the anti-apoptosis of cell transplantation, fibroblast growth factor and neurotrophic factor as humoral factors secreted by the transplanted cells have a protective effect on the neurons after cerebral infarction. Now review the local hypothermia and cell transplantation after cerebral infarction neuroprotection and its mechanism.