论文部分内容阅读
【目的】评估低位直肠癌手术前行改良新辅助放化疗+术中温热灌洗治疗的近期疗效及肿瘤的病理学改变,探索治疗低位直肠癌的新途径。【方法】45例低位直肠癌患者DukesB期(17)、DukesC期(28)随机分为:A组15例行自行设计改良的新辅助治疗:术前放疗、区域动脉介入微泵灌注化疗,按时辰多通道程控输液泵给药;B组15例,术前放疗+区域动脉介入一次性灌注化疗;C组15例诊断明确后手术;45例患者均行术中腹腔温热灌洗化疗。【结果】A、B、C组在术前降低肿瘤临床分期、提高保肛率和复发率方面相比较有显著性差异(P<0.05),A、B、C组肿瘤的病理改变相比较差异有统计学意义(P<0.05)。【结论】改良新辅助放化疗+术中腹腔温热灌洗化疗治疗低位直肠癌具有较好的临床疗效,能提高保肛率和生存率。
【Objective】 To evaluate the short-term effect of neoadjuvant chemoradiation and intraoperative warm lavage in the treatment of low rectal cancer and explore the pathological changes of the tumor, so as to explore a new way to treat low rectal cancer. 【Methods】 45 patients with low rectal cancer DukesB (17), DukesC (28) were randomly divided into: A group of 15 patients with self-designed and improved neoadjuvant therapy: preoperative radiotherapy, regional artery interventional micro-pump infusion chemotherapy Time multi-channel programmable infusion pump administration; B group of 15 patients, preoperative radiotherapy + regional artery interventional chemotherapy; C group of 15 patients diagnosed after surgery; 45 patients underwent intraperitoneal hyperthermic lavage chemotherapy. 【Results】 The results showed that the pathological changes of tumors in groups A, B and C were significantly lower than those in groups A, B and C before operation (P <0.05), and the rates of anal sphincter preservation and recurrence were significantly different There was statistical significance (P <0.05). 【Conclusion】 Modified neoadjuvant chemoradiotherapy + intraperitoneal hyperthermic lavage chemotherapy in the treatment of low rectal cancer has good clinical curative effect, can improve the anal sphincter preservation rate and survival rate.