Two new sesquiterpenes,trivially named ricinusoids A (1) and ricinusoids B (2),were isolated from ethyl acetate fraction of Ricinus communis.The structures of new compounds were elucidated by detailed spectroscopic techniques,including 1D-and 2D-NMR,UV,IR spectroscopy,and mass spectrometry.The compounds (1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5,10,and 20 mg-kg-1 i.p.Pretreatment of both test compounds caused significant (P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics.Both compounds (1-2) possessed marked sedative and antinociceptive effects in animal models.