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戊型肝炎最早在印度发现,随后相继在东南亚、中亚细亚、北非、墨西哥和中国等发生流行。1990年美国Reyes et al首先报告了戊型肝炎病毒克隆的部分基因序列,目前至少已有4株HEV全序列被阐明,包括缅甸株、墨西哥株、巴基斯坦株及中国新疆株。由于HEV基因序列的阐明,戊型肝炎的实验检测技术随之取得了很快进展,本文就近两年戊肝检测的最新进展作一综述,为了更好地理解这些方法的原理,首先简要说明HEV的基因结构。
Hepatitis E was first discovered in India and subsequently prevailed in Southeast Asia, Central Asia, North Africa, Mexico and China. In 1990, Reyes et al first reported some gene sequences of HEV clones. At present, at least 4 HEV sequences have been elucidated, including Myanmar, Mexico, Pakistani and China Xinjiang. Due to the HEV gene sequence elucidation, experimental detection technology of hepatitis E has made rapid progress. In this paper, the recent progress of detection of hepatitis E in recent two years is reviewed. In order to better understand the principle of these methods, a brief description of HEV The genetic structure.