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Dear Editor,rnSince December 2019,A new type of coronavirus pneumo-nia(coronavirus disease 2019,COVID-19)has become endemic in Wuhan,China.So far,COVID-19 has developed into a global epidemic.The body's immune system plays an important role in the fight against COVID-19.Here,we followed up the clinical data and treatment of two COVID-19 patients diagnosed with acquired immunodeficiency syn-drome(AIDS),hoping to be helpful for the subsequent diagnosis and treatment of patients with related diseases.