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目的探讨p16基因产物在肺癌中的表达及其临床意义。方法应用免疫组化SP法检测82例肺癌组织中p16基因表达并结合肺癌的临床病理学特征及预后情况进行分析，40例癌旁正常肺组织作对照。结果肺癌组织中P16基因产物阳性表达率为57．3％，癌旁正常肺组织为92.5％。肺癌组织中存在明显的P16基因表达缺失。肺癌组织中p16基因表达水平与肺癌的细胞分化程度、临床分期及预后有密切关系（P＜0．05）。结论p16基因表达缺失在肺癌发生、发展、分化和转归过程中起重要作用，检测肺癌组织中p16基因表达水平可作为判断肺癌进展和预后的一个重要参考指标。
Objective To investigate the expression of p16 gene in lung cancer and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of p16 gene in 82 cases of lung cancer and the clinicopathological characteristics and prognosis of lung cancer were analyzed. Forty normal lung tissues were used as control. Results The positive rate of P16 gene product in lung cancer was 57.3% and that in normal lung tissue was 92.5%. There is a significant loss of P16 gene expression in lung cancer tissues. The expression of p16 gene in lung cancer is closely related to the degree of cell differentiation, clinical stage and prognosis of lung cancer (P <0.05). Conclusion The loss of p16 gene expression plays an important role in the occurrence, development, differentiation and prognosis of lung cancer. Detecting the expression of p16 gene in lung cancer can be used as an important reference to judge the progress and prognosis of lung cancer.