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在肾脏疾病的进展过程中,转分化机制是重要的致纤维化机制,上皮细胞可能转分化为间充质细胞。本文综述间充质细胞在慢性肾脏疾病中的分子机制、病理意义和治疗干预方面的进展。
Transdifferentiation is an important fibrogenic mechanism during the progression of renal disease, and epithelial cells may transdifferentiate into mesenchymal cells. This review summarizes the molecular mechanisms of mesenchymal cells in chronic kidney disease, pathological significance and advances in therapeutic intervention.