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目的研究前列地尔脂微球载体制剂(Lipo-PGE1,简称前列地尔注射液,商品名:凯时)对急性有机磷农药中毒患者心肌保护的作用。方法将60例重度有机磷农药中毒患者随机分为2组,对照组(n=30)给予洗胃、氯解磷定、阿托品及对症处理;治疗组(n=30)在对照组治疗基础上加用前列地尔注射液10μg/d静脉滴注,连续7 d。同时监测心钙蛋白Ⅰ(cTnI)和肌酸激酶同工酶(CK-MB)及心电图变化。结果治疗组总有效率(93.3%)高于对照组(73.3%),差异有统计学意义(χ2=4.32,P<0.05)。治疗组治疗3、7d后血清中cTnI和CK-MB低于对照组(P<0.01),心电图异常率较对照组低(P<0.05)。结论前列地尔注射液对有机磷农药中毒患者心肌损伤具有保护作用。
Objective To study the effect of lipo-PGE1 (Lipo-PGE1) on cardioprotection in patients with acute organophosphorus pesticide poisoning. Methods Sixty patients with severe organophosphorus pesticide poisoning were randomly divided into two groups. The control group (n = 30) was given gastric lavage, chlorpromazine, atropine and symptomatic treatment. The treatment group (n = 30) Plus alprostadil 10μg / d intravenous infusion, continuous 7d. Simultaneous monitoring of cTnI and CK-MB and ECG changes. Results The total effective rate (93.3%) in the treatment group was higher than that in the control group (73.3%), the difference was statistically significant (χ2 = 4.32, P <0.05). Serum levels of cTnI and CK-MB were lower in the treatment group than those in the control group (P <0.01) after 3 and 7 days of treatment, and the abnormal rate of electrocardiogram was lower than that of the control group (P <0.05). Conclusion Alprostadil injection has a protective effect on myocardial injury in patients with organophosphate pesticide poisoning.