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目的了解血浆黏附分子颗粒膜蛋白（ＧＭＰ－１４０）水平及其在肾组织的表达与狼疮肾炎（ＬＮ）活动。肾脏病理及肾功能损害的关系。方法用酶联免疫吸附法（ＥＬＩＳＡ）测定血浆ＧＭＰ－１４０水平，并用免疫组织化学染色法，观察正常肾和狼疮肾组织ＧＭＰ－１４０表达。结果ＬＮ患者较正常人以及活动ＬＮ较非活动ＬＮ，血ＧＭＰ－１４０水平显著升高；ＬＮ紧组织ＧＭＰ－１４０表达较正常肾组织明显增强，且狼疮肾组织ＧＭＰ－１４０＋细胞数与血浆ＧＭＰ－１４０水平和狼疮肾活动指数明显正相关，与肾脏病理和功能损害有一定相关关系。结论ＧＭＰ－１４０在介导ＬＮ中起重要作用，其血浆水平或肾组织表达水平可作为反映ＬＮ活动和进行性肾损害的指标。
Objective To investigate the level of plasma adhesion molecule granule membrane protein (GMP-140) and its expression in renal tissue and lupus nephritis (LN) activity. Kidney pathology and renal dysfunction. Methods Plasma GMP-140 levels were measured by enzyme-linked immunosorbent assay (ELISA). The expression of GMP-140 in normal kidney and lupus nephritis tissues was observed by immunohistochemical staining. Results The level of GMP-140 in LN patients was significantly higher than that in normal subjects and active LNs. The expression of GMP-140 in LN tissues was significantly higher than that in normal renal tissues. The number of GMP-140 + 140 levels and lupus nephritis activity index was significantly positively correlated with renal pathological and functional impairment have a certain correlation. Conclusion GMP-140 plays an important role in mediating LN, and its plasma level or renal tissue expression level can be used as an indicator of LN activity and progressive renal damage.