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报告1例以掌部红斑为首发表现的系统性红斑狼疮(SLE)。患者女,34岁。因双掌部反复红斑伴疼痛6个月,溃疡1周就诊,并发脱发及光敏现象。实验室检查:贫血,淋巴细胞减少,尿蛋白、补体下降,抗核抗体(ANA)及抗双链(ds)-DNA阳性。皮损组织病理检查:表皮角化过度及角栓形成,基底细胞层液化变性;真皮浅、中层血管扩张,部分血管壁纤维素样坏死,周围少量淋巴组织细胞浸润及核尘。直接免疫荧光检查:基膜Ig G、Ig A及Ig M呈线状沉积。诊断为SLE。
One case of systemic lupus erythematosus (SLE) presenting with palpable erythema was reported. Female patient, 34 years old. Repeated erythema due to double palm with pain for 6 months, 1 week ulcer treatment, concurrent hair loss and photosensitivity. Laboratory tests: anemia, lymphopenia, urinary protein, decreased complement, anti-nuclear antibody (ANA) and anti-double-stranded (ds) -DNA positive. Skin lesions histological examination: epidermal hyperkeratosis and the formation of corner plug, liquefaction of the basal cell layer degeneration; dermal shallow, middle vasodilation, some vascular wall fibrosis, a small amount of lymphocytic infiltration and nuclear dust. Direct immunofluorescence examination: Basement membranes Ig G, Ig A and Ig M were linearly deposited. Diagnosed as SLE.