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[目的]研究脑梗塞患者血中一氧化氮(NO)的含量与血小板功能之间的关系.[方法]将20例脑梗塞患者分别于发病急性期和稳定期采用硝酸还原酶法测血中NO含量;用光电比浊法和免疫荧光分析法分别测定血小板聚集率(PAgT)和血小板α-颗粒膜蛋白(GMP-140)水平;同时检测正常对照15例[结果]血清中NO含量在发病急性期较正常对照明显增高(P<0.01).同时,PAgT与正常对照有显著性差异(PADP<0.05,PADR<0.01);而血小板GMP-140在急性期和稳定期较正常对照均有显著性差异(P<0.01).[结论]脑梗塞发病急性期随着血中NO含量的增高,导致PAgT受抑,血小板GMP-140水平减低.
[Objective] To study the relationship between blood nitric oxide (NO) and platelet function in patients with cerebral infarction. [Methods] Twenty patients with cerebral infarction were measured with nitrate reductase method at acute and stable stages respectively. (NO) content were measured. The levels of platelet aggregation (PAgT) and platelet α-granule membrane protein (GMP-140) were determined by photoelectric turbidimetry and immunofluorescence assay. 15 cases of normal control were also detected. [Results] PAgT was significantly different from the normal control (PADP <0.05, PADR <0.01), while the platelet GMP-140 in the acute phase and the stable phase were significantly higher than the normal control (P <0.01) (P <0.01). [Conclusions] The acute phase of cerebral infarction increases with the increase of NO in blood, which results in the suppression of PAgT and the decrease of platelet GMP-140 level.