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目的:观察光叶娃儿藤的解热和抗炎作用。方法:SD大鼠随机分为生理盐水对照组,阿司匹林组(0.1 g.kg-1),光叶娃儿藤低、中、高剂量组(6,12,24 g.kg-1)。分别采用酵母混悬液复制大鼠发热模型和角叉菜胶致大鼠足趾肿胀法,观察光叶娃儿藤的解热和抗炎作用,同时紫外分光光度法测定大鼠角叉菜胶致炎足渗出物中的前列腺素E2(PGE2)的含量。结果:与生理盐水组比较,光叶娃儿藤中、高剂量组(12,24 g.kg-1)能显著降低酵母菌致大鼠发热模型的体温(P<0.05),并能显著抑制角叉菜胶致大鼠的足肿胀度(P<0.05)和足组织中的前列腺素E2(PGE2)的合成(P<0.05)。结论:光叶娃儿藤具有明显的解热和抗炎作用,其机制可能与抑制PGE2等炎症介质合成有关。
OBJECTIVE: To observe the antipyretic and anti-inflammatory effects of light-leaf vines. Methods: SD rats were randomly divided into normal saline control group, aspirin group (0.1 g.kg-1), low, medium and high dose of Radix et phyleticus (6,12,24 g.kg-1). The rat model of fever and rat’s toe swelling induced by carrageenan were respectively prepared by yeast suspension. The antipyretic and anti-inflammatory effects were observed by spectrophotometry. The carrageenan The content of prostaglandin E2 (PGE2) in pro-inflammatory foot exudates. Results: Compared with the saline group, the medium and high dose groups (12 and 24 g · kg-1) could significantly reduce the body temperature (P <0.05) of the rat model of fever caused by yeast and could significantly inhibit Carrageenan-induced foot swelling in rats (P <0.05) and synthesis of prostaglandin E2 (PGE2) in foot tissues (P <0.05). Conclusion: The light-leaf vines have obvious antipyretic and anti-inflammatory effects, the mechanism may be related to inhibition of PGE2 and other inflammatory mediators.