制备了以三苯基膦(PPh_3)作为助剂的Ru-Rh/γ-Al_2O_3催化剂,在氢氧化钾的异丙醇溶液中,用(1S,2S)-DPEN[(1S,2S)-1,2-diphenylethane-1,2-diamine]作手性修饰剂对苯乙酮及其衍生物进行不对称催化加氢,此催化剂表现出较高的催化活性和良好的对映选择性.优化反应条件,苯乙酮、乙基苯基酮和异丙基苯基酮的转化率分别达到92.5%,95.9%,100%,生成(R)-构型产物的ee值分别达到79.6%、81.2%和81.4%. Ru-Rh / γ-Al_2O_3 catalyst was prepared with triphenylphosphine (PPh_3) as a promoter in a solution of (1S, 2S) -DPEN [(1S, 2S) -1 , 2-diphenylethane-1,2-diamine] as the chiral modifier for the asymmetric catalytic hydrogenation of acetophenone and its derivatives, the catalyst showed high catalytic activity and good enantioselectivity. Optimum reaction conditions , The conversions of acetophenone, ethyl phenyl ketone and isopropyl phenyl ketone reached 92.5%, 95.9% and 100%, respectively. The ee values ​​of (R) -configuration products reached 79.6%, 81.2% and 81.4%.