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目的:研究血小板功能变化与肝硬化的关系,并探讨其临床意义。方法:采用血细胞分析仪检测了91例肝炎后肝硬化患者血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)及血小板分布宽度(PDW),并与肝功能分级(Child—Pugh积分法)比较。结果:肝硬化组PLT、MPV、PCT较对照组均显著降低(P<0.01)或P<0.05),而PDW显著升高(P<0.01);肝硬化合并上消化道出血组PLT、MPV、PCT较无上消化道出血组均显著降低(P<0.01);肝功能A级组PLT、B级组PLT和MPV及C级组PLT、MPV、PCT较对照组均显著降低(P<0.01或P<0.05),C级组PDW较对照组显著升高(P<0.01),B级组PLT、MPV较A级组显著降低(P<0.01或P<0.05),C级组PLT、MPV、PCT较B级组均显著降低(P<0.01或P<0.05)。结论:血小板四项参数可间接反映血小板功能,对评估肝硬化患者肝脏功能损害的严重程度,判断有无出血倾向,指导临床治疗及其预后都具有重要的指导意义。
Objective: To study the relationship between platelet function changes and cirrhosis, and to explore its clinical significance. Methods: The platelet count (PLT), platelet volume (MPV), platelet pressure (PCT) and platelet distribution width (PDW) in 91 patients with posthepatitic cirrhosis were detected by hematology analyzer. Pugh integral method) comparison. Results: The levels of PLT, MPV and PCT in cirrhosis group were significantly lower than those in control group (P <0.01 or P <0.05), while PDW was significantly increased (P <0.01) (P <0.01 or P <0.01). The levels of PLT, MPV and PCT in PLT, B group and MPV group were significantly lower than those in control group (P <0.01 or P <0.01) (P <0.05). The PDW in C group was significantly higher than that in control group (P <0.01). The PLT and MPV in B group were significantly lower than those in A group (P <0.01 or P <0.05) PCT was significantly lower than the B group (P <0.01 or P <0.05). Conclusion: The four parameters of platelets indirectly reflect platelet function. It is of great significance to evaluate the severity of liver dysfunction in patients with liver cirrhosis, to determine whether bleeding tendency, to guide clinical treatment and prognosis.