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目的探讨锥切术对宫颈上皮内瘤样病变(CIN)患者治疗后生育的影响。方法对2002年5月至2010年5月在我院因CIN接受宫颈环形电切术(LEEP)治疗并有生育愿望的45例患者,观察其术后受孕情况及妊娠结局。结果观察组妊娠率为82.2%(37/45),对照组妊娠率为86.7%(39/45)。两组妊娠率差异无统计学意义(P>0.05)。两组在胎膜早破发生率和剖宫产率方面比较差异有统计学意义(P<0.05),两组在流产率、小于胎龄儿发生率和早产率方面差异无显著性(P>0.05)。结论宫颈环形电切术治疗CIN不影响患者术后的生育能力。可增加胎膜早破的风险,但并不增加早产及小于胎龄儿的发生率。
Objective To investigate the effect of conization on fertility of patients with cervical intraepithelial neoplasia (CIN) after treatment. Methods From May 2002 to May 2010 in our hospital for cervical CIN received cervical ring electrosurgical excision (LEEP) treatment and 45 patients with childbearing desire, observe the postoperative pregnancy and pregnancy outcome. Results The pregnancy rate was 82.2% (37/45) in observation group and 86.7% (39/45) in control group. There was no significant difference in pregnancy rates between the two groups (P> 0.05). There was significant difference between the two groups in the incidence of premature rupture of membranes and the rate of cesarean section (P <0.05). There was no significant difference between the two groups in terms of abortion rate, birth rate less than gestational age and rate of preterm birth (P> 0.05). Conclusion Cervical ring resection of CIN does not affect postoperative fertility. Can increase the risk of premature rupture of membranes, but does not increase the incidence of premature birth and less than gestational age children.