论文部分内容阅读
业已证实,人二倍体细胞狂犬病疫苗(HDCV)在美国和欧洲无论肌肉或皮内免疫人群,几乎100%产生足量的抗体应答。但是近来,一名美国和平队志愿者(PCV)在肯尼亚皮内接种标准的3针HDCV(Id)接触前预防后死于狂犬病,意外地发现其抗体阴性,并且与该死者同时接种同批疫苗的另外11名PCV中,有9人(82%)无抗体应答。本文报道了在美国和发展中国家作接触前免疫的效果。
It has been demonstrated that human diploid cell rabies vaccine (HDCV) produces a sufficient amount of an antibody response in almost 100% of the population in the United States and Europe irrespective of muscle or intradermal immunization. But recently, a U.S. Peace Corps volunteer (PCV) died of rabies after prophylaxis of a standard 3-gauge HDCV (Id) in Kenya intradermally, finding its antibody negative unexpectedly and receiving the same batch of vaccine with the deceased Of the other 11 PCVs, 9 (82%) had no antibody response. This article reports on the effects of pre-exposure immunization in the United States and in developing countries.