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目的 提高对遗传性非息肉病性大肠癌临床特性、诊断和治疗的认识。方法 对 7个有遗传性非息肉病性大肠癌家系进行调查。结果 7家系中有 2 1例发病者 ,年龄 2 6～ 79岁 ,平均年龄 46岁。 2 1例共有 31处大肠癌灶 ,其中 16处位于脾曲近端的大肠 ,10处位于脾曲远端的大肠 ,5处部位不详。 6 1 5 % (16 /2 6 )的癌灶位于脾曲近端的大肠。 6例患大肠多原发癌 ,占全组的 2 8 6 % (6 /2 1)。结论 对遗传性非息肉病性大肠癌患者及其家系成员要进行严密监测 ,争取早诊断早治疗 ,提高治疗效果。
Objective To improve the understanding of the clinical features, diagnosis and treatment of hereditary nonpolyposis colorectal cancer. Methods Seven pedigrees with hereditary nonpolyposis colorectal cancer were investigated. Results There were 21 cases of onset in 7 pedigrees, ranging in age from 26 to 79 years with a mean age of 46 years. There were 31 colorectal foci in 21 cases, of which 16 were located in the large intestine of splenic flexure, 10 were in the distal intestine of splenic flexure, and 5 were unknown. 61 5% (16/2 6) of the foci located in the proximal intestine of splenic flexure. Six cases of multiple primary colorectal cancer, the whole group of 286% (6/2 1). Conclusion Hereditary nonpolyposis colorectal cancer patients and their family members should be closely monitored for early diagnosis and early treatment and improve the therapeutic effect.