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目的探讨社区应用格列美脲分散片联合二甲双胍在2型糖尿病治疗中的临床效果。方法接受治疗2型糖尿病患者64例为观察组,另选取同期该症患者64例为对照组,对其社区用药情况进行回顾性分析,对照组单用二甲双胍治疗,观察组应用格列美脲分散片联合二甲双胍治疗,观察两组患者治疗3个月后降糖效果及不良反应情况。结果经3个月随访,观察组空腹血糖(FBG)、糖化血红蛋白(Hb Alc)及OGTT-2 h血糖值均明显低于对照组(P<0.05),观察组不良反应发生率为10.94%,对照组不良反应发生率为29.69%,差异具有统计学意义(P<0.05)。结论在2型糖尿病社区治疗中,采用格列美脲分散片与二甲双胍联合疗法,能有效提高降糖效果,改善患者症状,且安全性高,值得临床推广运用。
Objective To investigate the clinical effect of community-based glimepiride dispersible tablets combined with metformin in the treatment of type 2 diabetes mellitus. Methods Sixty-four patients with type 2 diabetes mellitus undergoing treatment were selected as the observation group. Sixty-four patients with the same disease were selected as the control group. The community medication was retrospectively analyzed. The control group was treated with metformin alone. The observation group was treated with glimepiride Tablets combined with metformin treatment, observed two groups of patients after 3 months of treatment hypoglycemic effect and adverse reactions. Results After three months of follow-up, the blood glucose levels of FBG, Hb Alc and OGTT-2 h in the observation group were significantly lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 10.94% The incidence of adverse reactions in the control group was 29.69%, the difference was statistically significant (P <0.05). Conclusion Community-based treatment of type 2 diabetes with glimepiride dispersible tablets and metformin combination therapy can effectively improve the hypoglycemic effect and improve the patient’s symptoms, and high safety, worthy of clinical promotion and use.