甲状腺生理一、甲状腺激素的合成、分泌和代谢垂体促甲状腺激素(TSH)促进甲状腺腺泡从碘化物合成甲状腺激素(T_4、T_3),并促进合成的 T_4、T_3自甲状腺球蛋白分离出来,释放入血。甲状腺腺泡有其自身的调节,如给予较大剂量的碘化物,则甲状腺腺泡中有机碘的形成减少,有机碘化合物的比例发生变化,T_3、T_4形成减少,一碘酪氨酸/二碘酪氨酸比值增高。碘化物对激素形成的抑制作用称为 Wolff-Chaikoff 效应。缺碘地区的甲状腺合成T_3多于 T_4,使碘得到最充分的利用。若碘化物过多,则通过 W-C 效应减少 T_3和 T_4的合成,从而不致 Thyroid physiology First, the synthesis, secretion and metabolism of thyroid hormones Pituitary thyroid stimulating hormone (TSH) promotes thyroid acinar thyroid hormone (T_4, T_3) synthesis from iodide and promotes the synthesis of T_4, T_3 from thyroglobulin isolated and released Into the blood. Thyroid acinar has its own regulation, such as given a larger dose of iodide, the thyroid gland in the formation of organic iodine decreased, the proportion of organic iodine compounds change, T_3, T_4 formation decreased, a iodine tyrosine / bis Iodine tyrosine ratio increased. The inhibitory effect of iodide on hormone formation is called the Wolff-Chaikoff effect. Thyroid synthesis of iodine-deficient areas T_3 more than T_4, iodine to get the fullest use. If iodide is too much, the synthesis of T_3 and T_4 is reduced by the W-C effect so that no