Analytical methods for nano-bio interface interactions

来源 :Science China(Chemistry) | 被引量 : 0次 | 上传用户:zhh6622692
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level. Knowledge on the interactions between engineered nanomaterials (ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano- bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface char acterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.
其他文献
[本刊讯]4月1日是上海市消防局机关大楼设立对外接待服务窗口的第一天,局长李铁山亲自坐堂,热情接待了前来办理各项消防业务的有关人员。这是市消防局继今年各区县防火监督处(科
日前,由中兴通讯承建的国内首个完全符合CTSI(Chinese Termainal Service Interface)标准的省级固网综合信息平台在江苏正式开通,将为江苏全省10万用户提供点对点发送短消息
以天安门为界,如果把媒体分为四种,广播、纸制、电视、网络,可以看到很多媒体在陆续转移到CBD区域之内,去年新浪网的搬家,引起了不小的震动。新浪网搬家东移,一个原因是广告
近10余年来研究表明,单纯疱疹病毒(HSV)除引起口眼等局部疾患,尚能产生某些严重病症,甚至危及生命,故受到普遍重视。HSV 系有包膜的 DNA 病毒。按其血清学、生物化学和生物
[本刊讯]5月26日,上体馆广场横幅高悬、彩旗飘扬。52支消安队、400余名消安队员、42辆消防车一大早便从四面八方赶赴这里聚集。上午9点正,市消防局司令部副参谋长焦洪元上校宣
〔本刊讯〕市防火安全委员会日前发出通知,要求各区、县、局(集团)公司防火安全委员会,做好今冬明春消防工作。通知指出,从11月9日起至明年2月底为本市重点防火季节,根据冬春季节风
●2013年8月24至25日(两天)●北京课程背景绩效管理对提高企业竞争力,实现可持续发展起着显著的支持作用。可为什么任何一个企业的高级管理者都对大量的绩效管理理论和方法耳
1980年和1982年对吉林省永吉、海龙、桦甸三县的华支睾吸虫病流行情况作了调查。永吉县桦皮厂公社星火大队粪检409名朝鲜族居民,虫卵阳性者124人,感染率为30.3%,海龙县城南公
对于通信行业来说,机房发生设备宕机是不能容忍的,这直接关系到企业的信誉、形象、用户数量乃至运营的收入。因此,在建立数据中心的过程中,需要认真考虑很多子系统。在许多
[本刊讯〕在参加’98上海高层建筑国际学术研讨会后,公安部消防局局长孙伦于11月2日至4日视察了本市消防工作。在沪期间,市委常委、市公安局局长刘云耕,市公安局副局长顾永和会见