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目的探讨精吡氟禾草灵原药致突变性及亚慢性毒性。方法按照GB15670-1995《农药登记毒理学试验方法》进行。结果精吡氟禾草灵原药致突变性的试验结果与对照组比较差异无统计学意义(P>0.05)。亚慢性毒性试验中:中、高剂量组雌鼠碱性磷酸酶(AKP)增高;雄鼠体重较对照组有明显减轻,肝脏和脑的脏器系数增高;高剂量组雄鼠肾脏脏器系数增高。结论本试验提示精吡氟禾草灵原药无明显致突变作用,对动物脑、肝、肾等脏器有损伤作用。SD大鼠亚慢性(90 d)经口毒性的最大无作用剂量雌、雄分别为6.8和8.4 mg/kg.d。
Objective To investigate the mutagenicity and subchronic toxicity of fluazifop-p-ethyl. Methods in accordance with GB15670-1995 “pesticide registration toxicology test method”. Results The test results of mutagenicity of fluazifop-p-ethyl were not significantly different from the control group (P> 0.05). In the sub-chronic toxicity test, alkaline phosphatase (AKP) increased in the medium and high dose groups; the body weight of the male mice was significantly reduced compared with the control group, and the organ coefficients in the liver and brain were increased; the organ coefficient Increase. Conclusion This test indicates that fluazifop-p-ethyl has no obvious mutagenic effect on animals, brain, liver, kidney and other organs damage. The maximal non-active dose of sub-chronic (90 d) oral toxicity in SD rats was 6.8 and 8.4 mg / kg.d respectively.