应用延期和二次手术治疗Ⅲ、Ⅳ期神经母细胞瘤１２例。术前化疗时间平均３．７９±２．０９月，ＣＴＸ化疗强度（ＤＩ）７３１．５±３５６．７ｍｇ·（ｍ￣２）￣（－１）／周。肿瘤切除率８３．３％，显著高于一期手术组（Ｐ＜０．０１）。重点探讨延期和二次手术的指征、时机和临床意义，强调延期和二次手术对Ⅲ、Ⅳ期神经母细胞瘤疗效提高和长期生存的积极作用。 Application of delayed and secondary surgery Ⅲ, Ⅳ neuroblastoma in 12 cases. The average preoperative chemotherapy time was 3.79 ± 2.09 months, and the CTX chemotherapy intensity (DI) was 731.5 ± 356.7 mg · (m ~ 2) ~ (-1) / week. The tumor resection rate was 83.3%, which was significantly higher than that of the first operation group (P <0.01). It focuses on the indications, timing and clinical significance of delaying and secondary surgery, emphasizing the positive effects of delaying and secondary surgery on the efficacy and long-term survival of stage Ⅲ and Ⅳ neuroblastoma.