肌萎缩性脊髓侧索硬化症是一种进行性运动神经元疾病,目前尚无对症疗法,有研究认为病因与兴奋性氨基酸神经递质谷氨酸盐有关。 作者对155名肌萎缩性侧索硬化症门诊患者用抗谷氨酸盐噻唑类药Riluzole进行双盲安慰剂对照试验以评价其作用及安全性。根据发病部位(延髓区或肢体)将患者随机分组,用药剂量每天为100毫 Amyotrophic lateral sclerosis is a progressive motor neuron disease, there is no symptomatic treatment, some studies suggest that the cause and excitatory amino acid neurotransmitter glutamate related. The authors conducted a double-blind, placebo-controlled trial of 155 patients with amyotrophic lateral sclerosis using the anti-glutamate-based thiazide Riluzole to assess their efficacy and safety. According to the site of disease (medulla or limbs) were randomly divided into groups, the dose of 100 milliliters per day